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KMID : 1156220130390010001
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Journal of Environmental Health Sciences
2013 Volume.39 No. 1 p.1 ~ p.18
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Endocrine Disruption Potentials of Bisphenol A Alternatives - Are Bisphenol A Alternatives Safe from Endocrine Disruption?
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Ji Kyung-Hee
Choi Kyung-Ho
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Abstract
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Objectives: Although a great body of knowledge is available on the toxicity of bisphenol A (BPA), little is known about that of BPA alternatives, such as bisphenol analogues (BPs) or TritanTM copolyesters. This review provides a summary of the available information on the toxicity of BPs and three components of TritanTM, with a special focus on endocrine disruption.
Methods: We collected from the literature a battery of in vitro and in vivo assay data developed to assess endocrine disruption of four BPs (bisphenol AF, B, F, and S) and three major components of TritanTM ((di-methylterephthalate (DMT), 1,4-cyclohexanedimethanol (CHDM), and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD)).
Results: Several alternative compounds were identified as possessing comparable or even greater endocrinedisrupting effects than BPA in in vitro and in vivo studies.
Conclusions: Potential endocrine disruption of BPA alternatives requires further studies on health consequences in experimental animals and in humans following longer term exposure.
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KEYWORD
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bisphenols, endocrine disruption, Tritan
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